Citalopram Hydrobromide | Neurotransmitter Transporters | Highly Potent & Selective 5-HT Uptake Inhibitor

Category:

Cat.No.	Product Name
1427	Citalopram hydrobromide

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Citalopram hydrobromide

Chemical Name: 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihy dro-5-isobenzofurancarbonitrile hydrobromide

Biological Activity:

Highly selective and potent 5-HT uptake inhibitor with no effect on noradrenaline or dopamine uptake (IC₅₀ values are 1.8, 8800 and 41000 nM respectively). Has negligible activity at a wide range of receptors and is clinically used as an antidepressant.

Technical Data:

M.Wt:	405.31
Formula:	C₂₀H₂₁FN₂O.HBr
Storage:	Store at RT
Solubility:	Soluble to 50 mM in Ethanol and to 10 mM in Water
Purity:	>99%
CAS No:	[59729-33-8]

Resources:

Certificate of Analysis / MSDS:

Certificate of Analysis: View current batch

Product/Material Safety Data Sheet: View current batch

References:

Hyttel (1982) Citalopram - pharmacological profile of a specific serotonin uptake inhibitor with antidepressant activity. Prog.Neuro-Psychopharmacol.Biol.Psychiat. 6 277. Auerbach and Hjorth (1995) Effect of chronic administration of the selective serotonin (5-HT) uptake inhibitor citalopram on extracellular 5-HT and apparent autoreceptor sensitivity in rat forebrain in vivo. Naunyn-Schmied.Arch.Pharmacol. 352 597. Mateo et al (2000) Inhibition of 5-hydroxytryptamine reuptake by the antidepressant citalopram in the locus coeruleus modulates the rat brain noradrenergic transmission in vivo. Neuropharmacology 39 2036.

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Keywords: Citalopram Hydrobromide, Neurotransmitter Transporters, Highly Potent & Selective 5-HT Uptake Inhibitor, Tocris Bioscience

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5-HT Receptors & their Ligands
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