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Category:
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7TM Receptors 5-HT Receptors5-HT4 ReceptorsAgonists
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Cat.No.
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Product Name
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1695 |
Cisapride
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| Alternative name(s): |
R 51619 |
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Price and Availability
Click here for full price details of
Cisapride
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Chemical Name:
(±)-4-Amino-5-chloro-N-[1-[(3R*,4S*)-3-(4-fluorophenoxy
)propyl]-3-methoxy-4-piperidinyl]-2-methoxybenzamide |
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Biological Activity:
5-HT4 receptor agonist and
gastrokinetic agent. Stimulates intestinal acetylcholine release, possibly via
5-HT4 receptor-dependent and -independent mechanisms, leading to increased
intestinal motility.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Schuurkes et al (1985)
Motor-stimulating properties of cisapride on isolated gastrointestinal
preparations of the guinea pig. J.Pharmacol.Exp.Ther. 234 775. Taniyama
et al (1991) Cisapride stimulates motility of the intestine via the
5-hydroxytryptamine receptors. J.Pharmacol.Exp.Ther. 258 1098. Briejer
et al (1993) Cisapride and a structural analogue, R 76,186, are
5-hydroxytryptamine4 (5-HT4) receptor agonists on the
guinea-pig colon ascendens. Naunyn-Schmied.Arch.Pharmacol. 347
464.
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or by Research Area
Keywords: Cisapride, 5-HT Receptors, 5-HT4 Agonist; Stimulates Intestinal ACh Release, R 51619, Tocris Bioscience
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