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Category:
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Nuclear Receptors PPAR Receptors
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Cat.No.
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Product Name
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1307 |
Ciglitazone
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Price and Availability
Click here for full price details of
Ciglitazone
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Chemical Name:
5-[[4-[(1-Methylcyclohexyl)methoxy]phenyl]methyl]-2,4-t
hiazolidinedione |
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Biological Activity:
Selective agonist at PPARγ
(peroxisome proliferator-activated receptor γ).
Activates PPARγ with an EC50
value of 3 μM in vitro, and is at
least 33-fold selective over PPARα
and δ. Antihyperglycemic in vivo.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Willson et al (1996) The structure-activity relationship between
peroxisome proliferator receptor γ agonism and the
antihyperglycemic activity of thiazolidinediones. J.Med.Chem. 39
665. Jha (1999) Thiazolidinediones - the new insulin enhancers.
Clin.Exp.Hypertens. 21 157. Xin et al (1999)
Peroxisome proliferator-activated receptor γ ligands are potent
inhibitors of angiogenesis in vitro and in vivo. J.Biol.Chem. 274
9116.
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Keywords: Ciglitazone, PPAR Receptors, Selective PPARg Agonist, Tocris Bioscience
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