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Category:
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Ion Channels Potassium ChannelsVoltage-Gated Potassium Channels
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Cat.No.
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Product Name
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1412 |
Chromanol 293B
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Price and Availability
Click here for full price details of
Chromanol 293B
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Chemical Name:
trans-N-[6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-
1-benzopyran-4-yl]-N-methyl-ethanesulfonamide |
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Biological Activity:
Blocker
of the slow delayed rectifier K+ current (IKs) (IC50
= 1-10 μM). Also blocks the CFTR chloride current (ICFTR)
(IC50 = 19 μM).
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Fujisawa et al (2000) Time-dependent
block of the slowly activating delayed rectifier K(+) current by chromanol 293B
in guinea-pig ventricular cells. Br.J.Pharmacol. 129 1007. Bachmann
et al (2001) Chromanol 293B, a blocker of the slow delayed rectifier K+
current (IKS), inhibits the CFTR Cl- current.
Naunyn-Schmied.Arch.Pharmacol. 363 590. Sun et al
(2001) Chromanol 293B inhibits slowly activating delayed rectifier and
transient outward currents in canine left ventricular myocytes.
J.Cardiovasc.Electrophysiol. 12 472.
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or by Research Area
Keywords: Chromanol 293B, Potassium Channels, IKs Blocker. Also Blocks ICFTR, Tocris Bioscience
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Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
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