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Category: Ion ChannelsarrowLigand-gated Ion Channelsarrow5-HT3 ReceptorsarrowAgonists
Cat.No. Product Name
0440 m-Chlorophenylbiguanide hydrochloride  
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m-Chlorophenylbiguanide hydrochloride
Chemical Name: 1-(3-Chlorophenyl)biguanide hydrochloride

Biological Activity:

Prototypical potent and selective 5-HT3 receptor agonist.

Technical Data:

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M.Wt: 248.11
Formula: C8H10CIN5.HCl
Storage: Desiccate at RT
Solubility: Soluble to 100 mM in Water
Purity: >98%
CAS No: [2113-05-5]

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    References:

    Kilpatrick et al (1990) 1-(m-Chlorophenyl)biguanide, a potent high affinity 5-HT3 receptor agonist. Eur.J.Pharmacol. 182 193. Sepulveda et al (1991) The agonist properties of m-chlorophenylbiguanide and 2-methyl-5-hydroxytryptamine on 5-HT3 receptors in N1E-115 neuroblastoma cells. Br.J.Pharmacol. 104 536. Boess et al (1992) 5HT3 receptors in NG108-15 neuroblastoma X glioma cells: effect of the novel agonist 1-(m-chlorophenyl)biguanide. Neuropharmacology 31 561. Niemeyer and Lummis (1998) Different efficacy of specific agonists at 5-HT3 receptor splice variants: the role of the extra six amino acid segment. Br.J.Pharmacol. 123 661.

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    Keywords: M-Chlorophenylbiguanide Hydrochloride, Ligand-gated Ion Channels, Potent & Specific 5-HT3 Agonist, Meta-Chlorophenylbiguanide Hydrochloride, Tocris Bioscience
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