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Cat.No. Product Name
0237

7-Chlorokynurenic acid  

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7-Chlorokynurenic acid
Chemical Name: 7-Chloro-4-hydroxyquinoline-2-carboxylic acid

Biological Activity:

NMDA receptor antagonist acting at the glycine site. Potent competitive inhibitor of L-glutamate transport into synaptic vesicles.

Technical Data:

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M.Wt: 223.62
Formula: C10H6CINO3
Storage: Store at RT
Solubility: Soluble to 100 mM in DMSO and to 100 mM in 1eq. NaOH
Purity: >98%
CAS No: [18000-24-3]

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    References:

    Kemp et al (1988) 7-Chlorokynurenic acid is a selective antagonist of the glycine modulatory site of the NMDA receptor complex. Proc.Natl.Acad.Sci.USA 85 6547. Donald et al (1988) Characterization of the [3H]-glycine binding to a modulatory site within the NMDA receptor complex from rat brain. Br.J.Pharmacol. 95 892P. Kretschmer et al (1995) Behavioral and neurochemical actions of the strychnine-insensitive glycine receptor antagonist, 7-chlorokynurenate, in rats. Eur.J.Pharmacol. 280 37. Bartlett et al (1998) Substituted quinolines as inhibitors of L-glutamate transport into synaptic vesicles. Neuropharmacology 37 839.
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    Keywords: 7-Chlorokynurenic Acid, Neurotransmitter Transporters, Potent Competitive Inhibitor Of L-glutamate Uptake, 7Chlorokynurenic Acid, Tocris Bioscience

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