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Category:
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Nuclear Receptors Retinoic Acid Receptors
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Cat.No.
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Product Name
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2020 |
Ch 55
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Price and Availability
Click here for full price details of
Ch 55
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Chemical Name:
4-[(1E)-3-[3,5-bis(1,1-Dimethylethyl)phenyl]-3-oxo-1-pr
openyl]benzoic acid |
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Biological Activity:
Highly potent synthetic retinoid that has high affinity for RAR-α and RAR-β receptors and low
affinity for cellular retinoic acid binding protein (CRABP). Inhibits rabbit
tracheal epithelial cell differentiation by inhibiting transglutaminase and
increasing cholesterol sulfate (EC50 values are 0.02 and 0.03 nM
respectively). Induces differentiation of embryonic carcinoma F9 and melanoma
S91 cells (EC50 values are 0.26 and 0.5 nM respectively) and
inhibits the induction of ornithine decarboxylase activity in 3T6 fibroblasts
(EC50 = 1 nM).
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
Certificate of Analysis is currently unavailable on-line. Please contact Customer Service
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References:
Jetten et al (1987) New benzoic acid derivatives with retinoid
activity: lack of direct correlation between biological activity and binding to
cellular retinoic acid binding protein. Cancer Res. 47 3523. Sato
et al (1988) Functional studies of newly sythesized benzoic acid
derivatives: identification of highly potent retinoid-like activity.
J.Cell.Physiol. 135 179. Hashimoto et al (1990)
Expression of retinoic acid receptor genes and the ligand-binding selectivity of
retinoic acid receptors (RAR's). Biochem.Biophys.Res.Comm. 166
1300.
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Keywords: Ch 55, Retinoic Acid Receptors, Potent Retinoic Acid Receptor (RAR) Agonist, Ch55, Tocris Bioscience
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