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Chemical Name:[1S-(1a,6b,7a,8b,8ab)]-Octahydro-1,6,7,8-indolizinetetr
ol
Biological Activity:
Potent inhibitor of α- and β-glucosidases, especially glucosidase l (required for
glucoprotein processing by transfer of mannose and glucose from
asparagine-linked lipids).Inhibits HIV
syncytium formation and replication.
Saul et al (1984) Studies on the mechanism of castanospermine inhibition of α- and β-glucosidases.
Arch.Biochem.Biophys. 230 668. Gruters et al (1987)
Interference with HIV-induced syncytium formation and viral infectivity by
inhibitors of trimming glucosidase. Nature 330 74. Welkeret
al (1987) Inhibition of HIV
syncytium formation and virus replication by castanospermine. Proc.Natl.Acad.Sci.USA
84 8120.
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