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Category:
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7TM Receptors Adrenergic ReceptorsGeneral Beta Receptors
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Cat.No.
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Product Name
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2685 |
Carvedilol
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| Alternative name(s): |
BM 14190 |
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Price and Availability
Click here for full price details of
Carvedilol
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Chemical Name:
1-(9H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]a
mino]-2-propanol |
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Biological Activity:
Potent β-adrenoceptor
and α1-adrenoceptor antagonist
(Ki values are 0.81, 0.96 and 2.2 nM for β1-, β2- and α1-adrenoceptors
respectively) that displays antihypertensive and peripheral vasodilatory
activity. Blocks cardiac inward-rectifier K+ (KIR)
channels, voltage-dependent Ca2+ channels and exhibits antioxidant
properties at higher concentrations.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Ohlstein et al
(1993) Carvedilol, a cardiovascular drug, prevents vascular smooth muscle cell
proliferation, migration, and neointimal formation following vascular injury.
Proc.Natl.Acad.Sci.USA. 90 6189. Ponicke et al
(2002) Differential effects of bucindolol and carvedilol on
noradrenaline-induced hypertonic response in ventricular cardiomyocytes of
adult rats. J.Pharmacol.Exp.Ther. 301 71. Kikuta et al
(2006) Carvedilol blocks cardiac KATP and KG but not IK1
channels by acting at the bundle-crossing region. Eur.J.Pharmacol. 529
47.
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Keywords: Carvedilol, Adrenergic Receptors, B-adrenoceptor & A1-adrenoceptor Antagonist, BM 14190, Tocris Bioscience
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