Watkinset al (1987) Recent advances in the pharmacology of
excitatory amino acids. In Excitatory Amino Acid Transmission. Eds. Hicks,
Lodge & McLennan, pp 19-26, Liss, New York. Hayashi et al (1994) Analysis of agonist and
antagonist activities of phenylglycine derivatives for different cloned
metabotropic glutamate receptor sub-types. J.Neurosci. 14 3370. Watkins
and Collingridge (1994) Phenylglycine derivatives as antagonists of
metabotropic glutamate receptors. TiPS 15 333. Sekiyamaet
al (1996) Structure-activity relationships of new agonists and antagonists
of different metabotropic glutamate receptor subtypes. Br.J.Pharmacol. 117
1493.
Keywords: (S)-3-Carboxy-4-hydroxyphenylglycine, Glutamate (Metabotropic) Receptors, Group I Antagonist / Group II Agonist, (S)-3C4HPG, 3Carboxy-4-hydroxyphenylglycine, Tocris Bioscience
Displays 26-fold and > 440-fold selectivity over kainate and NMDA receptors respectively. Neuro-protective; delays neuronal death in a global ischaemia model and cerebral infarction in a focal ischaemia model.
