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Carboxy-PTIO, potassium salt
Other Information:
Not for sale in Japan
Chemical Name:2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-ox
yl-3-oxide, potassium salt
Biological Activity:
A stable, water-soluble free radical that reacts
stoichiometrically with NO. Almost twice as strong an inhibitor as N(ω)-nitroarginine or N-methylarginine.
Akaike et al (1993) Antagonistic action of imidazolineoxy N-oxides
against endothelium-derived relaxing factor/NO through a radical reaction.
Biochemistry 32 827. Tsunodaet al (1994)
Vasodilator effect of carboxy-2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl in
the coronary circulation: in vivo and in vitro studies.
Eur.J.Pharmacol. 262 55. Rand and Li (1995) Discrimination
by the NO-trapping agent, carboxy-PTIO, between NO and the nitrergic
transmitter but not between NO and EDRF. Br.J.Pharmacol. 116 1906.
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