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(E)-Capsaicin
Chemical Name:(E)-N-[(4-Hydroxy-3-methoxyphenyl)methyl]-8-methyl-6-no
nenamide
Biological Activity:
Prototypic vanilloid receptor agonist (pEC50 values are
7.97 and 7.10 at rat and human VR1 receptors respectively). Excites a subset of
primary afferent sensory neurons, with subsequent antinociceptive and
anti-inflammatory effects. Reversibly inhibits aggregation of platelets.
Bevan and Szolcsani (1990) Sensory neuron-specific actions of
capsaicin: mechanisms and application. TiPS 11 330. Hogaboam
and Wallace (1991) Inhibition of platelet aggregation by capsaicin. An
effect unrelated to actions on sensory afferent neurons. Eur.J.Pharmacol. 202
129. Holzer (1991) Capsaicin-cellular targets, mechanism of
actions, and selectivity for thin sensory neurons. Pharmacol.Rev. 43 143.
Ralevic et al (2001) Cannabinoid activation of recombinant and
endogenous vanilloid receptors. Eur.J.Pharmacol. 424 211.
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