Camptothecin | Isomerases | DNA Topoisomerase Inhibitor

Category:

Cat.No.	Product Name
1100	Camptothecin

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Camptothecin

Chemical Name: (S)-4-Ethyl-4-hydroxy-1H-pyrano-[3',4':6,7]indolizino[1 ,2-b]quinoline-3,14(4H,12H)-dione

Biological Activity:

Cytotoxic plant alkaloid with antitumour properties; prototypic DNA topoisomerase I inhibitor.

Technical Data:

M.Wt:	348.36
Formula:	C₂₀H₁₆N₂O₄
Storage:	Desiccate at +4°C
Solubility:	Soluble to 5 mM in DMSO
Purity:	>98%
CAS No:	[7689-03-4]

Resources:

Certificate of Analysis / MSDS:

Certificate of Analysis: View current batch

Product/Material Safety Data Sheet: View current batch

References:

Merck Index 12 1783. Liu (1989) DNA topoisomerase poisons as antitumour drugs. Ann.Rev.Biochem. 58 351. Pantazis et al (1993) Camptothecin derivatives induce regression of human ovarian carcinomas grown in nude mice and distinguish between non-tumorigenic and tumorigenic cells in vitro. Int.J.Cancer 53 863. Onishi et al (1993) Topoisomerase inhibitors induce apoptosis in thymocytes. Biochim.Biophys.Acta 1175 147.

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Keywords: Camptothecin, Isomerases, DNA Topoisomerase Inhibitor, Tocris Bioscience

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