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Category: EnzymesarrowKinasesarrowProtein Kinase C
Cat.No. Product Name
1626 Calphostin C
Alternative name(s): UCN 1028C
Price and Availability

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Calphostin C
Chemical Name: (1R)-2-[12-[(2R)-2-(Benzoyloxy)propyl]-3,10-dihydro-4,9 -dihydroxy-2,6,7,11-tetramethoxy-3,10-dioxo-1-perylenyl ]-1-methylethylcarbonic acid 4-hydroxyphenyl ester

Biological Activity:

Potent, selective and photo-dependent inhibitor of protein kinase C that targets the regulatory domain (IC50 = 50 nM). Displays > 1000-fold selectivity over other protein kinases such as cAMP-dependent protein kinase and tyrosine-specific protein kinase. Inhibits cell proliferation of malignant glioma cells in light-treated conditions in vitro (IC50 ~ 40-60 nM).

Technical Data:

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M.Wt: 790.76
Formula: C44H38O14
Storage: Desiccate at +4°C
Solubility: Soluble in DMSO and in Ethanol
CAS No: [121263-19-2]

Resources:

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    • Certificate of Analysis / MSDS:

    Certificate of Analysis: View current batch
    Product/Material Safety Data Sheet: View current batch

    References:

    Kobayashi et al (1989) Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C. Biochem.Biophys.Res.Comm. 159 548. Pollack and Kawecki (1997) The effect of calphostin C, a potent photodependent protein kinase C inhibitor, on the proliferation of glioma cells in vitro. J.Neurooncol. 31 255. Au et al (2006) Differential effects of photofrin, 5-aminolevulinic acid and calphostin C on glioma cells. J.Photochem.Photobiol.B. 85 92.
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    Keywords: Calphostin C, Kinases, Potent, Selective & Photo-dependent PKC Inhibitor, UCN 1028C, Tocris Bioscience
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