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Category:
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Cellular Processes and Components Signal TransductionCytokine and NFkB SignallingNFkB/IkB
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Cat.No.
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Product Name
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2743 |
Caffeic acid phenethyl ester
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| Alternative name(s): |
CAPE |
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Price and Availability
Click here for full price details of
Caffeic acid phenethyl ester
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Chemical Name:
3-(3,4-Dihydroxyphenyl)-2-propenoic acid 2-phenylethyl
ester |
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Biological Activity:
Antioxidant, antimitogenic, anticarcinogenic,
anti-inflammatory and antiviral. Specifically inhibits NF-kB activation and
inhibits the growth of transformed cells. Also suppresses lipid peroxidation
and inhibits ornithine decarboxylase, protein tyrosine kinase and lipoxygenase
activities.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Sud'ina et al
(1993) Caffeic acid phenethyl ester as a lipoxygenase inhibitor with
antioxidant properties. FEBS Lett. 329 21. Natarajan et
al (1996) Caffeic acid phenethyl ester is a potent and specific inhibitor
of activation of nuclear transcription factor NF-κB. Proc.Natl.Acad.Sci.USA 93
9090. Fitzpatrick et al (2001) Caffeic acid phenethyl ester, an
inhibitor of nuclear factor-κB,
attenuates bacterial peptidoglycan polysaccharide-induced colitis in rats.
J.Pharmacol.Exp.Ther. 299 915.
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View related products by Pharmacological Action
or by Research Area
Keywords: Caffeic Acid Phenethyl Ester, Signal Transduction, Specific Inhibitor Of NF-kB Activation, CAPE, Tocris Bioscience
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Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
Product Feature
Proteasome and NF-κB
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Proteasome & calpain inhibitor. Inhibits NF-κB activation
2637
Gliotoxin
Immunosuppressant; inhibits NF-κB & cytokine production
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