Corticotropin-releasing
factor binding protein (CRFBP) inhibitor peptide; displaces CRF from CRFBP.
Suppresses body weight gain and increases motor activity in obese rats in vivo.
Heinrichset al (2001) Dissociation of
arousal-like from anxiogenic-like actions of brain corticotropin-releasing
factor receptor ligands in rats. Behav.Brain Res. 122 43. Heinrichset al (2001) Selective stimulatory actions of corticotropin-releasing
factor ligands on correlates of energy balance. Physiol.Behav. 74
5. Jahnet al (2002) The binding protein of
corticotropin-releasing factor: ligand-binding site and subunit structure.
Proc.Natl.Acad.Sci.USA 99 12055.
Blocks CRF-induced adenylate cyclase activation (Ki = 3.7 nM) and attenuates activation of the HPA axis by CRF. Displays anxiolytic-like activity in the rat elevated plus-maze test; brain penetrant.