CP 809101 Hydrochloride | 5-HT Receptors | Potent & Selective 5-HT2C Agonist | CP809101 Hydrochloride

Category:

Cat.No.	Product Name
3041	CP 809101 hydrochloride

Price and Availability

Click here for full price details of
CP 809101 hydrochloride

Chemical Name: 2-[(3-Chlorophenyl)methoxy]-6-(1-piperazinyl)pyrazine hydrochloride

Biological Activity:

Potent and selective 5-HT_2C receptor agonist (pEC₅₀ values are 9.96, 7.19 and 6.81 for human 5-HT_2C, 5-HT_2B and 5-HT_2A receptors respectively). Displays antipsychotic activity; suppresses condition avoidance responding (CAR) and inhibits PCP and amphetamine-stimulated hyperactivity in rats following subcutaneous administration.

Technical Data:

M.Wt:	341.24
Formula:	C₁₅H₁₇N₄OCl.HCl
Storage:	Desiccate at RT
Solubility:	Soluble to 20 mM in Water and to 100 mM in DMSO
Purity:	>99%
CAS No:	[479683-64-2]

Resources:

Certificate of Analysis / MSDS:

Certificate of Analysis: View current batch

For specific/earlier batch please select:

Product/Material Safety Data Sheet: View current batch

For specific/earlier batch please select:

References:

Siuciak et al (2007) CP-809,101, a selective 5-HT_2C agonist, shows activity in animal models of antipsychotic activity. Neuropharmacol. 52 279. Kalgutkar et al (2007) Genotoxicity of 2-(3-chlorobenzyloxy)-6-(piperazinyl)pyrazine, a novel 5-hydroxytryptamine2c receptor agonist for the treatment of obesity: role of metabolic activation. Drug Metab.Dispos. 35 848.

View related products by Pharmacological Action or by Research Area

Keywords: CP 809101 Hydrochloride, 5-HT Receptors, Potent & Selective 5-HT2C Agonist, CP809101 Hydrochloride, Tocris Bioscience

Literature in this Area

Scientific Reviews

5-HT Receptors & their Ligands
Download PDF

Featured New Product

Selective 5-HT₇ antagonist

2726 SB 258719

Selective 5-HT₇ receptor antagonist that displays > 100-fold selectivity over a range of other receptors. Reverses the hypothermic effect of 5-CT in mice following i.p. administration.

View all Featured New Products

New Products in this Area

	3041	CP 809101 hydrochloride
	Potent and selective 5-HT_2C agonist
	3085	Ziprasidone hydrochloride
	5-HT_2A/D₂ antagonist; atypical antipsychotic
	1985	PNU 142633
	Highly selective 5-HT_1D agonist
	2643	DOI hydrochloride
	Mixed 5-HT_2A/2C agonist
	2901	SB 242084
	Selective 5-HT_2C antagonist; brain penetrant
	2925	LP 12 hydrochloride
	5-HT₇ agonist
	2726	SB 258719 hydrochloride
	Selective 5-HT₇ antagonist
	2739	U 92016A
	Selective 5-HT_1A agonist
	2865	Risperidone
	5-HT_2A antagonist
	2746	Amperozide hydrochloride
	Atypical antipsychotic; high affinity 5-HT₂ ligand
	2844	Mosapride citrate
	5-HT₄ agonist and 5-HT₃ antagonist
	2777	Nefazodone hydrochloride
	5-HT_2A antagonist and 5-HT uptake inhibitor. Antidepressant
	2645	Fananserin
	5-HT_2A antagonist. Also D₄ antagonist
	2592	TCB-2
	Potent, high affinity 5-HT_2A agonist
	2495	Melperone hydrochloride
	5-HT_2A/D₂ receptor antagonist; neuroleptic
	2451	LY 344864 hydrochloride
	Potent, selective 5-HT_1F agonist
	2534	LP 44
	High affinity 5-HT₇ agonist

for new product e-alerts

User ID
Password