|
Category:
|
Ion Channels Potassium ChannelsVoltage-Gated Potassium Channels
|
|
Cat.No.
|
Product Name
|
|
1399 |
CP 339818 hydrochloride
|
|
|
|
Price and Availability
Click here for full price details of
CP 339818 hydrochloride
|
|
Chemical Name:
N-[1-(Phenylmethyl)-4(1H)-quinolinylidene]-1
pentanamine hydrochloride |
|
|
Biological Activity:
Potent, non-peptide KV1.3 channel
antagonist that preferentially binds to the C-type inactivated state of the
channel (IC50 ~ 200 nM) . Inhibits KV1.4 with an IC50
of ~ 300 nM. Selective over KV1.1, KV1.2, KV1.5,
KV1.6, KV3.1-4, and KV4.2.
|
Technical Data:
|
|
|
Resources:
|
|
Certificate of Analysis / MSDS:
|
References:
Nguyen et al (1996) Novel nonpeptide
agents potently block the C-type inactivated conformation of Kv1.3 and suppress
T cell activation. Mol.Pharmacol. 50 1672. Jager et al
(1998) Regulation of mammalian Shaker-related K+ channels:
evidence for non-conducting closed and non-conducting inactivated. J.Physiol. 506
291.
|
|
View related products by Pharmacological Action
or by Research Area
Keywords: CP 339818 Hydrochloride, Potassium Channels, Non-peptide, Potent KV1.3 Channel Blocker, CP339818 Hydrochloride, Tocris Bioscience
|
|
Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
| “Tocris is to be congratulated for continuing to meet the current demand for a rapid and reliable source of high-quality compounds that are urgently needed as pharmacological tools by a growing international population of cannabinoid researchers..” Researcher, University of Aberdeen, UK |
|
