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Category:
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7TM Receptors Peptides (Hypothalamic/Pituitary Hormones)CRF Receptors
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Cat.No.
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Product Name
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2779 |
CP 154526
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Price and Availability
Click here for full price details of
CP 154526
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Chemical Name:
N-Butyl-N-ethyl-2,5-dimethyl-7-(2,4,6-trimethylphenyl)-
7H-pyrrolo[2,3-d]pyrimidin-4-amine hydrochloride |
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Biological Activity:
Selective, non-peptide CRF1 receptor
antagonist (Ki values are 2.7 and > 10000 nM for CRF1
and CRF2 receptors respectively). Blocks CRF-induced adenylate
cyclase activation (Ki = 3.7 nM) and attenuates activation of the
HPA axis by CRF. Displays anxiolytic-like activity in the rat elevated
plus-maze test; brain penetrant.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Lundkist et al
(1996) A non peptidic corticotropin releasing factor receptor antagonist
attenuates fever and exhibits anxiolytic activity. Eur.J.Pharmacol. 309
195. Schulz et al (1996) CP-154,526: a potent and selective
nonpeptide antagonist of corticotropin releasing factor receptors.
Proc.Natl.Acad.Sci.USA 93 10477. Hodgson et al
(2007) Comparison of the V1b antagonist, SSR149415, and the CRF1 antagonist,
CP-154,526, in rodent models of anxiety and depression.
Pharmacol.Biochem.Behav. 86 431.
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or by Research Area
Keywords: CP 154526, Peptides (Hypothalamic / Pituitary Hormones), Selective, Non-peptide CRF1 Antagonist, CP154526, Tocris Bioscience
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