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8-CPT-2Me-cAMP
Other Information:
Sold with
the permission of Biolog Life Science Institute
Chemical Name:8-(4-Chlorophenylthio)-2'-O-methyladenosine-3',5'-cycli
c monophosphate sodium salt
Biological Activity:
Selective
activator of Epac, the cAMP-sensitive guanine nucleotide-exchange factor for
Rap1 and Rap2. Activates Epac1 (EC50 = 2.2 μM), but not PKA (EC50 >
10 μM). Stimulates Epac-mediated Ca2+-mediated Ca2+
release in pancreatic β-cells in vitro.
Kawasaki et al (1998) A family of cAMP-binding
proteins that directly activate Rap1. Science 282 2275. Enserinket al (2002) A novel Epac-specific cAMP analogue demonstrates
independent regulation of Rap1 and ERK. Nature Cell Biol. 4 901. Kanget al (2003) Epac-selective cAMP analog 8-pCPT-2'-O-Me-cAMP as a
stimulus for Ca2+-induced Ca2+ release and exocytosis in
pancreatic β-cells.
J.Biol.Chem. 278 8279.
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