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Category: Ion ChannelsarrowLigand-gated Ion ChannelsarrowGlutamate (Ionotropic) ReceptorsarrowNMDA SelectivearrowNMDA SitearrowAntagonists
Cat.No. Product Name
1265 D-CPP-ene
Alternative name(s): Midafotel
SDZ EAA 494
Price and Availability

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D-CPP-ene
Chemical Name: D-4-[(2E)-3-Phosphono-2-propenyl]-2-piperazinecarboxyli c acid

Biological Activity:

Potent and competitive NMDA antagonist (Ki = 40 nM). Centrally active following systemic administration.

Technical Data:

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M.Wt: 250.19
Formula: C8H15N2O5P
Storage: Desiccate at RT
Solubility: Soluble to 100 mM in Water
CAS No: [117414-74-1]

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    References:

    Aebischer et al (1989) 115. Synthesis and NMDA antagonistic properties of the enantiomers of 4-(3-phosphonopropyl)piperazine-2-carboxylic acid (CPP) and of the unsaturated analogue (E)-4-(3-phosphono-2-enyl)piperazine-2-carboxylic acid (CPP-ene). Helv.Chim.Acta 72 1043. Lowe et al (1990) D-CPP-ene (SDZ EAA 494), a potent and competitive N-methyl-D-aspartate (NMDA) antagonist: effect on spontaneous activity and NMDA-induced depolarizations in the rat neocortical slice preparation, compared with other CPP derivatives and MK-801. Neurosci.Lett. 113 315. Potschka et al (1999) Effects of the NMDA receptor antagonist D-CPPene on extracellular levels of dopamine and dopamine and serotonin metabolites in striatum of kindled and non-kindled rats. Eur.J.Pharmacol. 374 175.
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    Keywords: D-CPP-ene, Ligand-gated Ion Channels, Potent, Competitive NMDA Antagonist, Midafotel, SDZ EAA 494, DCPP-ene, Tocris Bioscience
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