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Chemical Name:7-(Hydroxyimino)cyclopropa[b]chromen-1a-carboxylate
ethyl ester
Biological Activity:
hmGlu1 subtype selective non-competitive antagonist (IC50
= 6.5 μM). Has no agonist or
antagonist activity at hmGlu2, 4a, 5a, 7b, 8a or ionotropic
receptors at concentrations of up to 100 μM.
Annouraet al (1996) A novel class of
antagonists for metabotropic glutamate receptors,
7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxylates. Bioorg.Med.Chem.Lett. 6
763. Hermanset al (1998) Reversible and non-competitive
antagonist profile of CPCCOEt at the human type 1α metabotropic glutamate
receptor. Neuropharmacology 37 1645. Litschiget al
(1999) CPCCOEt, a noncompetitive metabotropic glutamate receptor 1 antagonist,
inhibits receptor signaling without affecting glutamate binding. Mol.Pharmacol.
55 453.
