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Category: Ion ChannelsarrowLigand-gated Ion ChannelsarrowGlutamate (Ionotropic) ReceptorsarrowAMPA / Kainate SelectivearrowAntagonists
Cat.No. Product Name
0190 CNQX  
Price and Availability

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CNQX
Chemical Name: 6-Cyano-7-nitroquinoxaline-2,3-dione

Biological Activity:

Potent AMPA/kainate receptor antagonist. Also antagonist at glycine modulatory site on NMDA receptor complex.

Technical Data:

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M.Wt: 232.16
Formula: C9H4N4O4
Storage: Store at RT
Solubility: Soluble to 100 mM in DMSO
Purity: >99%
CAS No: [115066-14-3]

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    References:

    Honore et al (1988) Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists. Science 241 701. Watkins et al (1990) Structure-activity relationships in the development of excitatory amino acid receptor agonists and competitive antagonists. TiPS 11 25. Long et al (1990) Effect of 6-cyano-2,3-dihydroxy-7-nitro-quinoxaline (CNQX) on dorsal root-, NMDA-, kainate and quisqualate-mediated depolarization of rat motoneurones in vitro. Br.J.Pharmacol. 100 850. King et al (1992) Antagonism of synaptic potentials in ventral horn neurones by 6-cyano-7-nitroquinoxaline-2,3-dione: a study in the rat spinal cord in vitro. Br.J.Pharmacol. 107 375.
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    Keywords: CNQX, Ligand-gated Ion Channels, Potent AMPA / Kainate Antagonist, Tocris Bioscience
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