Chemical Name:5-[(2R)-2-[[(2R)-2-(3-Chlorophenyl)-2-hydroxyethyl]amin
o]propyl]-1,3-benzodioxole-2,2-dicarboxylic acid
disodium salt
Biological Activity:
Potent and highly selective β3-adrenoceptor
agonist (EC50 = 3 nM); > 10000-fold selective over β1
and β2
receptors. Increases brown adipose tissue thermogenesis and metabolic rate, and
decreases blood insulin and glucose levels following oral administration in
vivo.
Bloomet al (1992)
Disodium(R,R)-5-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]-amino]propyl]-1,3-benzodioxole-2,2-dicarboxylate
(CL 316,243). A potent β-adrenergic agonist virtually
specific for β3 receptors. A promising antidiabetic and antiobesity
agent. J.Med.Chem. 35 3081. Yoshidaet al (1994)
Anti-obesity and anti-diabetic effects of CL 316,243, a highly specific β3-adrenoceptor agonist, in yellow KK mice. Life Sci. 54
491. Woodset al (2001) Efficacy of the β3-adrenergic receptor agonist CL-316243 on experimental
bladder hyperflexia and detrusor instability in the rat. J.Urol. 166
1142.
