CHPG | Glutamate (Metabotropic) Receptors | MGlu5 Selective Agonist

Category:

Cat.No.	Product Name
1049	CHPG

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CHPG

Chemical Name: (RS)-2-Chloro-5-hydroxyphenylglycine

Biological Activity:

A selective mGlu₅ metabotropic glutamate receptor agonist, completely inactive at mGlu_1a receptors expressed in CHO cells. Active in vivo.

Technical Data:

M.Wt:	201.61
Formula:	C₈H₈NO₃Cl
Storage:	Store at RT
Solubility:	Soluble to 100 mM in 1.1eq. NaOH
Purity:	>99%

Resources:

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References:

Doherty et al (1997) (RS)-2-Chloro-5-hydroxyphenylglycine (CHPG) activates mGlu₅, but not mGlu₁, receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus. Neuropharmacology 36 265. Salt et al (1999) Antagonism of the mGlu5 agonist 2-chloro-5-hydroxyphenylglycine by the novel selective mGlu5 antagonist 6-methyl-2-(phenylethynyl)-pyridine (MPEP) in the thalamus. Br.J.Pharmacol. 127 1057. Bao et al (2001) Selective mGluR5 receptor antagonist or agonist provides neuroprotection in a rat model of focal cerebral ischaemia. Brain Res. 922 173.

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Keywords: CHPG, Glutamate (Metabotropic) Receptors, MGlu5 Selective Agonist, Tocris Bioscience

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