Chemical Name:9-Chloro-2-(2-furanyl)-[1,2,4]triazolo[1,5-c]quinazolin
-5-amine
Biological Activity:
Potent
adenosine receptor antagonist (Ki values are 3.5, 4.2, 16 and 51 nM
for human A1, A2A, A2B and A3
receptors respectively). Orally active in vivo.
Williams
et al (1987) Biochemical characterization
of the triazoloquinazoline CGS 15943, a novel, non-xanthine adenosine
antagonist. J.Pharmacol.Exp.Ther. 241 415. Ghai et al (1987)
Pharmacological characterization of CGS 15943A: a novel nonxanthine adenosine
antagonist. J.Pharmacol.Exp.Ther. 242 784. Klotz (2000)
Adenosine receptors and their ligands. Naunyn-Schmied.Arch.Pharmacol. 362
382.
