CGS 12066B Dimaleate | 5-HT Receptors | 5-HT1B Agonist | CGS12066B Dimaleate

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Cat.No.	Product Name
0638	CGS 12066B dimaleate

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CGS 12066B dimaleate

Chemical Name: 7-Trifluoromethyl-4-(4-methyl-1-piperazinyl)pyrrolo[1,2 -a]-quinoxaline dimaleate

Biological Activity:

5-HT_1B full agonist, 10-fold selective over 5-HT_1A and 1000-fold selective over 5-HT_2C receptors. Centrally active following systemic administration.

Technical Data:

M.Wt:	566.49
Formula:	C₁₇H₁₇F₃N₄.2C₄H₄O₄
Storage:	Store at RT
Solubility:	Soluble to 5 mM in Water and to 40 mM in DMSO
CAS No:	[109028-10-6]

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Certificate of Analysis / MSDS:

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References:

Neale et al (1987) Biochemical and pharmacological characterization of CGS 12066B, a selective serotonin-1B agonist. Eur.J.Pharmacol. 136 1. Schoeffter and Hoyer (1989) Interaction of arylpiperazines with 5-HT_1A, 5-HT_1B, 5-HT_1C and 5-HT_1D receptors: do discriminatory 5-HT_1B receptor ligands exist? Naunyn-Schmied.Arch.Pharmacol. 339 675. Tomkins and O'Neill (2000) Effect of 5-HT(1B) receptor ligands on self-administration of ethanol in an operant procedure in rats. Pharmacol.Biochem.Behav. 66 129.

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Keywords: CGS 12066B Dimaleate, 5-HT Receptors, 5-HT1B Agonist, CGS12066B Dimaleate, Tocris Bioscience

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