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Category: EnzymesarrowKinasesarrowOther Kinases
Cat.No. Product Name
2731 CGP 57380
Price and Availability

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CGP 57380
Chemical Name: N3-(4-Fluorophenyl)-1H-pyrazolo-[3,4-d]pyrimidine-3,4-d iamine

Biological Activity:

Inhibitor of MAP-kinase interacting kinase-1 (Mnk1, MKNK1) (IC50 = 2.2 μM) that displays selectivity over p38, JNK1, ERK1, ERK2, PKC and c-src family kinases. Blocks phosphorylation of eIF4E in cellular assays (IC50 = 3 μM) and inhibits LPS-induced TNFα expression in macrophages.

Technical Data:

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M.Wt: 244.23
Formula: C11H9FN6
Storage: Store at +4°C
Solubility: Soluble to 100 mM in DMSO
Purity: >98%
CAS No: [522629-08-9]

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    • Certificate of Analysis / MSDS:

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    References:

    Knauf et al (2001) Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2. Mol.Cell.Biol. 21 5500. Ishida et al (2003) Mnk1 is required for angiotensin II-induced protein synthesis in vascular smooth muscle cells. Circ.Res. 93 1218. Andersson and Sundler (2006) Posttranscriptional regulation of TNFα expression via eukaryotic initiation factor 4E (eIF4E) phosphorylation in mouse macrophages. Cytokine 33 52.
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    Keywords: CGP 57380, Kinases, Selective Inhibitor Of Mnk1, CGP57380, Tocris Bioscience
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