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Category:
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7TM Receptors GABAB ReceptorsAntagonists
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Cat.No.
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Product Name
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1248 |
CGP 55845
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Price and Availability
Click here for full price details of
CGP 55845
Other Information:
Sold
with the permission of Novartis Pharma AG
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Chemical Name:
(2S)-3-[[(1S)-1-(3,4-Dichlorophenyl)ethyl]amino-2-hydro
xypropyl](phenylmethyl)phosphinic acid |
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Biological Activity:
Potent,
selective GABAB receptor antagonist (IC50 = 6 nM).
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Davies et al (1993) CGP 55845A: a potent antagonist of GABAB
receptors in the CA1 region of rat hippocampus. Neuropharmacology 32
1071. Lacey and Curtis (1994) Phosphinic acid derivatives as baclofen
agonists and antagonists in the mammalian spinal cord: an in vivo study.
Exp.Brain Res. 101 59. Cunninghan and Enna (1996) Evidence
for pharmacologically distinct GABAB receptors associated with cAMP
production in rat brain. Brain Res. 720 220. Froestl et
al (1996) Potent, orally active GABAB receptor antagonists.
Pharmacol.Rev.Comm. 8 127. Deisz (1999) The GABAB
antagonist CGP 55845A reduces presynaptic GABAB actions in neurons
of the rat in vitro. Neuroscience 93 1241.
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Keywords: CGP 55845, GABAB Receptors, Potent, Selective GABAB Antagonist, CGP55845, Tocris Bioscience
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