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Category:
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7TM Receptors GABAB ReceptorsAntagonists
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Cat.No.
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Product Name
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1246 |
CGP 52432
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Price and Availability
Click here for full price details of
CGP 52432
Other Information:
Sold
with the permission of Novartis Pharma AG
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Chemical Name:
3-[[(3,4-Dichlorophenyl)methyl]amino]propyl]
diethoxymethyl)phosphinic acid |
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Biological Activity:
Potent,
selective GABAB receptor antagonist (IC50 = 85 nM).
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Lanza et al (1993) CGP 52432: a novel potent and selective GABAB
autoreceptor antagonist in rat cerebral cortex. Eur.J.Pharmacol. 237
191. Froestl et al (1996) Potent, orally active GABAB
receptor antagonists. Pharmacol.Rev.Comm. 8 127. Bonanno et
al (1998) GABAB receptors as potential targets for drugs able to
prevent excessive excitatory amino acid transmission in the spinal cord.
Eur.J.Pharmacol. 362 143. Libri et al (1998)
Blockade of GABAB receptors facilitates muscarinic agonist-induced
epileptiform activity in immature rat piriform cortex in vitro.
Naunyn-Schmied.Arch.Pharmacol. 358 168.
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Keywords: CGP 52432, GABAB Receptors, Potent, Selective GABAB Antagonist, CGP52432, Tocris Bioscience
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