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Category: Ion ChannelsarrowLigand-gated Ion ChannelsarrowGlutamate (Ionotropic) ReceptorsarrowNMDA SelectivearrowNMDA SitearrowAntagonists
Cat.No. Product Name
1409 CGP 39551
Price and Availability

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CGP 39551
Chemical Name: (E)-(±)-2-Amino-4-methyl-5-phosphono-3-pentenoic acid ethyl ester

Biological Activity:

Potent, selective and competitive NMDA antagonist (Ki = 310 nM for inhibition of [3H]-CPP binding in rat brain). Centrally active upon oral administration in vivo.

Technical Data:

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M.Wt: 237.19
Formula: C8H16NO5P
Storage: Desiccate at +4°C
Solubility: Soluble to 100 mM in Water
Purity: >99%
CAS No: [127910-32-1]

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    References:

    Fagg et al (1990) CGP 37849 and CGP 39551: novel and potent competitive N-methyl-D-asparate receptor antagonists with oral activity. Br.J.Pharmacol. 99 791. Loscher and Honack (1991) Anticonvulsant and behavioural effects of two novel competitive N-methyl-D-aspartic acid receptor antagonists, CGP 37849 and CGP 39551, in the kindling model of epilepsy. Comparison with MK-801 and carbamazepine. J.Pharmacol.Exp.Ther. 256 432. D'Hooge et al (1999) Effects of competitive NMDA receptor antagonists on excitatory amino-acid-evoked currents in mouse spinal cord. Fundam.Clin.Pharmacol. 13 67.
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    Keywords: CGP 39551, Ligand-gated Ion Channels, Potent, Selective & Competitive NMDA Antagonist. Brain Penetrant In Vivo, CGP39551, Tocris Bioscience
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