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Category: Ion ChannelsarrowLigand-gated Ion ChannelsarrowGlutamate (Ionotropic) ReceptorsarrowNMDA SelectivearrowNMDA SitearrowAntagonists
Cat.No. Product Name
1469 CGP 37849
Price and Availability

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CGP 37849
Chemical Name: (E)-(±)-2-Amino-4-methyl-5-phosphono-3-pentenoic acid

Biological Activity:

Potent, selective and competitive NMDA receptor antagonist (Ki = 35 nM). Anticonvulsive following oral administration in vivo.

Technical Data:

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M.Wt: 209.14
Formula: C6H12NO5P
Storage: Desiccate at +4°C
CAS No: [127910-31-0]

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    References:

    Pozza et al (1990) Electrophysiological characterization of a novel potent and orally active NMDA receptor antagonist: CGP 37849 and its ethylester CGP 39551. Eur.J.Pharmacol. 182 91. Fagg et al (1990) CGP 37849 and CGP 39551: novel and potent competitive N-methyl-D-asparate receptor antagonists with oral activity. Br.J.Pharmacol. 99 791. Loscher and Honack (1991) Anticonvulsant and behavioural effects of two novel competitive N-methyl-D-aspartic acid receptor antagonists, CGP 37849 and CGP 39551, in the kindling model of epilepsy. Comparison with MK-801 and carbamazepine. J.Pharmacol.Exp.Ther. 256 432.
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    Keywords: CGP 37849, Ligand-gated Ion Channels, Potent Selective NMDA Antagonist. Orally Active, CGP37849, Tocris Bioscience
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