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Category:
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7TM Receptors Adrenergic ReceptorsBeta-1 Receptors
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Cat.No.
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Product Name
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1024 |
CGP 20712 dihydrochloride
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Price and Availability
Click here for full price details of
CGP 20712
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Chemical Name:
1-[2-((3-Carbamoyl-4-hydroxy)phenoxy)ethylamino]-3-[4-(
1-methyl-4-trifluoromethyl-2-imidazolyl)phenoxy]-2-prop
anol dihydrochloride |
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Biological Activity:
Highly selective and potent β1-adrenoceptor antagonist
(IC50 = 0.7 nM). Displays 10,000-fold selectivity over β2-adrenoceptors.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Dooley et al (1986) CGP 20712A: a useful tool for quantitating β1- and β2-adrenoceptors. Eur.J.Pharmacol. 130
137. Kitagawa et al (1995) Determination of β-adrenoceptor
subtype on rat isolated ventricular myocytes by use of highly selective β-antagonists.
Br.J.Pharmacol. 116 1635. Hieble et al (1995) α-and
β-adrenoceptors. From the gene to the clinic. 1. Molecular biology
and adrenoceptor subclassification. J.Med.Chem. 38 3415.
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Keywords: CGP 20712, Adrenergic Receptors, Highly Potent & Selective B1 Antagonist, CGP20712, Tocris Bioscience
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