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Category: TransportersarrowNeurotransmitter TransportersarrowGlutamate Transporters
Cat.No. Product Name
0332 L-CCG-lll  
Alternative name(s): (2S,3S,4R)-CCG
Price and Availability

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L-CCG-lll
Chemical Name: (2S,1'S,2'R)-2-(Carboxycyclopropyl)glycine

Biological Activity:

Potent and competitive inhibitor of both glial and neuronal uptake of glutamate, aspartate and cysteate.

Technical Data:

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M.Wt: 159.14
Formula: C6H9NO4
Storage: Store at RT
Solubility: Soluble to 100 mM in 1eq. NaOH
CAS No: [117857-95-1]

Resources:

  • Certificate of Analysis / MSDS:

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    References:

    Shinozaki et al (1989) Potent NMDA-like actions and potentiation of glutamate responses by conformational variants of a glutamate analogue in the rat spinal cord. Br.J.Pharmacol. 98 1213. Kawai et al (1992) 2-Carboxycyclopropyl)glycine: binding, neurotoxicity and induction of intracellular free Ca2+ increase. Eur.J.Pharmacol. 211 195. Nakamura et al (1993) (2S,3S,4R)-2-(Carboxycyclopropyl)glycine, a potent and competitive inhibitor of both glial and neuronal uptake of glutamate. Neuropharmacology 32 833. Yamashita et al (1995) Inhibition by folded isomers of L-2-(carboxycyclopropyl)glycine of glutamate uptake via the human glutamate transporter hGluT-I. Eur.J.Pharmacol. 289 387.
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    Keywords: L-CCG-lll, Neurotransmitter Transporters, Potent, Competitive Uptake Inhibitor, (2S,3S,4R)-CCG, LCCG-lll, Tocris Bioscience

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