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Category: 7TM ReceptorsarrowGlutamate (Metabotropic) ReceptorsarrowGroup II mGlu ReceptorsarrowAgonists
Cat.No. Product Name
0333

L-CCG-l  

Alternative name(s): (2S,3S,4S)-CCG
Price and Availability

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L-CCG-l
Chemical Name: (2S,1'S,2'S)-2-(Carboxycyclopropyl)glycine

Biological Activity:

Potent group II metabotropic glutamate receptor agonist (more active than glutamate or (±)-trans-ACPD (0187)).

Technical Data:

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M.Wt: 159.14
Formula: C6H9NO4
Storage: Store at RT
Solubility: Soluble to 100 mM in 1eq. NaOH
Purity: >99%
CAS No: [117857-93-9]

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    References:

    Shinozaki et al (1989) Potent NMDA-like actions and potentiation of glutamate responses by conformational variants of a glutamate analogue in the rat spinal cord. Br.J.Pharmacol. 98 1213. Hayashi et al (1992) Agonist analysis of 2-(carboxycyclopropyl)glycine isomers for cloned metabotropic glutamate receptor subtypes expressed in Chinese hamster ovary cells. Br.J.Pharmacol. 107 539. Wright and Schoepp (1996) Differentiation of group 2 and group 3 metabotropic glutamate receptor cAMP responses in the rat hippocampus. Eur.J.Pharmacol. 297 275. Brabet et al (1998) Comparative effect of L-CCG-I, DCG-IV and γ-carboxy-L-glutamate on all cloned metabotropic glutamate receptor subtypes. Neuropharmacology 37 1043.
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    Keywords: L-CCG-l, Glutamate (Metabotropic) Receptors, Potent Group II MGlu Agonist, (2S,3S,4S)-CCG, LCCG-l, Tocris Bioscience

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