Butabindide Oxalate | Proteases | CCK-inactivating Serine Peptidase Inhibitor

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Cat.No.	Product Name
1323	Butabindide oxalate

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Butabindide oxalate

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Sold with the permission of INSERM and UCL

Chemical Name: (2S)-[1-[(2S)-2-amino-1-oxobutyl]-N-butyl]-2,3-dihydro- 1H-indole-2-carboxamide oxalate

Biological Activity:

Potent, reversible, selective and competitive inhibitor of a CCK-inactivating serine peptidase (tripeptidyl peptidase II) (K_i = 7 nM). Active in vivo (ID₅₀ = 1.1 and 6.8 mg/kg i.v. for inhibition of liver and brain enzyme respectively).

Technical Data:

M.Wt:	393.44
Formula:	C₁₇H₂₅N₃O₂.C₂H₂O₄
Storage:	Desiccate at -20°C
Solubility:	Soluble to 100 mM in Water
Purity:	>99%
CAS No:	[175553-48-7]

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Certificate of Analysis / MSDS:

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References:

Rose et al (1996) Characterization and inhibition of a cholecystokinin-inactivating serine peptidase. Nature 380 403. Renn et al (1998) Characterization and cloning of tripeptidyl peptidase II from the fruit fly, Drosophila melanogaster. J.Biol.Chem. 273 19173. Ganellin et al (2000) Inhibitors of tripeptidyl peptidase II. 2. Generation of the first novel lead inhibitor of cholecystokinin-8-inactivating peptidase: a strategy for the design of peptidase inhibitors. J.Med.Chem. 43 664.

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Keywords: Butabindide Oxalate, Proteases, CCK-inactivating Serine Peptidase Inhibitor, Tocris Bioscience

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