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Category: 7TM ReceptorsarrowHistamine ReceptorsarrowH2 ReceptorsarrowAntagonists
Cat.No. Product Name
1857 Burimamide oxalate
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Burimamide
Chemical Name: N-[4-(1H-Imidazol-4-yl)butyl]-N'-methylthiourea oxalate

Biological Activity:

Histamine H3/H2 receptor antagonist (Ki values are 0.07, 7.8 and 290 μM for H3, H2 and H1 receptors respectively). Displays partial agonist activity in SK-N-MC cells. Produces antinociceptive effects following intraventricular administration (ED50 = 183 nmol/mouse in hot-plate test).

Technical Data:

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M.Wt: 302.35
Formula: C9H16N4S.C2H2O4
Storage: Desiccate at +4°C
Solubility: Soluble to 100 mM in Water and to 100 mM in DMSO
CAS No: [34970-69-9]

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    • Certificate of Analysis / MSDS:

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    Product/Material Safety Data Sheet: View current batch

    References:

    Lamberti et al (1996) Investigation into the role of histamine receptors in rodent antinociception. Pharmacol.Biochem.Behav. 53 567. Hough et al (2000) Antinociceptive activity of derivatives of improgran and burimamide. Pharmacol.Biochem.Behav. 65 61. Wieland et al (2001) Constitutive activity of histamine H3 receptors stably expressed in SK-N-MC cells: display of agonism and inverse agonism by H3 antagonists. J.Pharmacol.Exp.Ther. 299 908.
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    Keywords: Burimamide, Histamine Receptors, Mixed H2 / H3 Antagonist, Tocris Bioscience
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