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Category:
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Transporters Neurotransmitter TransportersDopamine Transporters
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Cat.No.
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Product Name
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2831 |
Bupropion hydrochloride
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Price and Availability
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Bupropion hydrochloride
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Chemical Name:
1-(3-Chlorophenyl)-2-[(1,1-dimethylethyl)amino]-1-propa
none hydrochloride |
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Biological Activity:
Non-selective inhibitor of dopamine and
noradrenaline transporters (Ki values are 1.4, 2.8 and 45 μM for NET,
DAT and SERT transporters respectively). Also inhibits neuronal nicotinic
acetylcholine receptors. Displays antidepressant activity and augments nicotine
self-administration at low doses in vivo.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Slemmer et al
(2000) Bupropion is a nicotinic antagonist. J.Pharmacol.Exp.Ther. 295
321. Torres et al (2003) Plasma membrane monoamine transporters:
structure regulation and function. Nat.Rev.Neurosci. 4 13. Dwoskin
et al (2006) Review of the pharmacology and clinical profile of
bupropion, antidepressant and tobacco use cessation agent. CNS Drug Rev. 12
178.
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Keywords: Bupropion Hydrochloride, Neurotransmitter Transporters, Non-selective Inhibitor Of Dopamine & Noradrenalin Transporters, Tocris Bioscience
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