Bucindolol | Adrenergic Receptors | B1- & B2-adrenoceptor Antagonist | MJ 13105

Category:

7TM Receptors

Adrenergic Receptors

General Beta Receptors

Cat.No.

Product Name

2658

Bucindolol

Alternative name(s):

MJ 13105

Bucindolol C22H25N3O2 2-[2-Hydroxy-3-[[2-(1H-indol-3-yl)-1,1-dimethylethyl]amino]propoxy]benzonitrile

Price and Availability

Click here for full price details of
Bucindolol

Chemical Name: 2-[2-Hydroxy-3-[[2-(1H-indol-3-yl)-1,1-dimethylethyl]am ino]propoxy]benzonitrile

Biological Activity:

Non-selective β-adrenoceptor antagonist with additional α₁-adrenoceptor blocking activity. K_i values are 1.61, 1.20 and 68.9 nM for β₁-, β₂- and α₁-adrenoceptors respectively. Also acts as a weak 5-HT_2A/2B antagonist. Displays vasodilatory and antihypertensive actions.

Technical Data:

M.Wt:	363.45
Formula:	_C22H25N3O2
Storage:	Store at +4°C
Solubility:	Soluble to 100 mM in DMSO and to 50 mM in Ethanol
Purity:	>99%
CAS No:	[71119-11-4]

Resources:

Certificate of Analysis / MSDS:

Certificate of Analysis: View current batch

For specific/earlier batch please select:

Product/Material Safety Data Sheet: View current batch

For specific/earlier batch please select:

References:

Marwood and Stokes (1985) Bucindolol has serotonin and alpha-adrenoceptor blocking properties. J.Cardiovasc.Pharmacol. 7 (Suppl. 7) S67. Watts et al (2000) Interaction of the [beta] adrenergic receptor antagonist bucindolol with serotonergic receptors. J.Cardiovasc.Pharmacol. 35 29. Ponicke et al (2002) Differential effects of bucindolol and carvedilol on noradrenaline-induced hypertrophic response in ventricular cardiomyocytes of adult rats. J.Pharmacol.Exp.Ther. 301 71.

View related products by Pharmacological Action or by Research Area

Keywords: Bucindolol, Adrenergic Receptors, B1- & B2-adrenoceptor Antagonist, MJ 13105, Tocris Bioscience

Literature in this Area

Scientific Reviews

Adrenoceptor Pharmacology
Download PDF

Unique & Diverse Compound Libraries

Tocriscreen Collections : For pricing and compound information click here

Fully annotated small molecule libraries for HTS, HCS and
chemical biology applications.

1120 compounds
Pre-dissolved in DMSO

Tocriscreen Total (250 μL/well)
Tocriscreen Mini (50 μL/well)

New Products in this Area

	2964	Doxazosin mesylate
	α₁-adrenoceptor antagonist
	1051	Zinterol hydrochloride
	Selective β₂ agonist
	2958	DSP-4
	Adrenergic neurotoxin
	2838	(R)-(-)-Phenylephrine hydrochloride
	α₁-adrenoceptor agonist
	2806	Alprenolol hydrochloride
	β antagonist
	2398	SNAP 5089
	Subtype selective α_1A-adrenoceptor antagonist
	2638	ST 91
	α₂ agonist, putative α_2C agonist
	2685	Carvedilol
	β-adrenoceptor and α₁-adrenoceptor antagonist
	2658	Bucindolol
	β₁- and β₂-adrenoceptor antagonist
	2666	JP 1302 dihydrochloride
	Potent and selective α_2C antagonist
	1811	Modafinil
	Psychostimulant

for new product e-alerts

User ID
Password