Chemical Name:1,6,7,8,9,11ab,12,13,14,14aa-Decahydro-1b,13a-dihydroxy
-6b-methyl-4H-cyclopent(f)oxacyclotridecin-4-one
Biological Activity:
Reversible inhibitor of protein translocation from the endoplasmic
reticulum (ER) to the Golgi apparatus. Blocks binding of ADP-ribosylation
factor to the Golgi apparatus and inhibits GDP-GTP exchange.
Ktistakiset al (1992) Action of brefeldin A blocked by activation
of a pertussis-toxin-sensitive G protein. Nature 356 344. Tsaiet al (1994) Identification of a brefeldin A-insensitive guanine
nucleotide-exchange protein for ADP-ribosylation factor in bovine brain.
Proc.Natl.Acad.Sci.USA 91 3063. Morinagaet al
(1996) Isolation of a brefeldin A-inhibited guanine nucleotide-exchange protein
for ADP ribosylation factor (ARF)1 and ARF3 that contains a Sec7-like domain.
Proc.Natl.Acad.Sci.USA 93 12856.
