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Category:
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Cellular Processes and Components Cytoskeleton and Motor ProteinsMyosin Related
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Cat.No.
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Product Name
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1852 |
(S)-(-)-Blebbistatin
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Price and Availability
Click here for full price details of
Blebbistatin, (-)-
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Chemical Name:
(3aS)-(-)-1,2,3,3a-Tetrahydro-3a-hydroxy-6-methyl-1-phe
nyl-4H-pyrrolo[2,3-b]quinolin-4-one |
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Biological Activity:
Selective inhibitor of myosin II ATPase activity
(IC50 ~0.5-5 μM);
active enantiomer of (±)-blebbistatin (Cat. No. 1760). Inhibits contraction of
the cleavage furrow without disrupting mitosis or contractile ring assembly.
Rapidly and reversibly blocks cell blebbing, and disrupts directed cell
migration and cytokinesis in vertebrate cells.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Straight et al
(2002) Dissecting cytokinesis with small molecules. Amer.Soc.Cell Biol.Abstr.
2515. Straight et al (2003) dissecting temporal and spatial
control of cytokinesis with a myosin II inhibitor. Science 299
1743. Limouze et al (2004) Specificity of blebbistatin, an
inhibitor of myosin II. J.Mus.Res.Cell Motil. 25 337.
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or by Research Area
Keywords: Blebbistatin, (-)-, Cytoskeleton & Motor Proteins, Selective Inhibitor Of Myosin II. Active Enantiomer, Blebbistatin,, Tocris Bioscience
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Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
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