Nor-Binaltorphimine Dihydrochloride | Opioid Receptors | Standard K Selective Antagonist | Nor-BNI | Norbinaltorphimine | NorBinaltorphimine Dihydrochloride

Category:

7TM Receptors

Opioid Receptors

Kappa Receptors

Antagonists

Cat.No.

Product Name

0347

nor-Binaltorphimine dihydrochloride

Alternative name(s):	nor-BNI
	Norbinaltorphimine

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nor-Binaltorphimine dihydrochloride

Other Information:

Sold with the permission of the University of Minnesota

Chemical Name: 17,17'-(Dicyclopropylmethyl)-6,6',7,7'-6,6'-imino- 7,7'-binorphinan-3,4',14,14'-tetrol dihydrochloride

Biological Activity:

A selective κ-opioid receptor antagonist.

Technical Data:

M.Wt:	734.72
Formula:	C₄₀H₄₃N₃O₆.2HCl
Storage:	Store at RT
Solubility:	Soluble to 25 mM in Water
Purity:	>98%
CAS No:	[105618-26-6]

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References:

Portoghese et al (1994) Structure-activity relationship of N17'-substituted norbinaltorphimine congeners. Role of the N17'-basic group in the interaction with a putative address subsite on the κ opioid receptor. J.Med.Chem. 37 1495. Blake et al (1997) Differential agonist regulation of the human κ-opioid receptor. J.Neurochem. 68 1846. Feng et al (1997) Nor-binaltorphimine precipitates withdrawal and excitatory amino acid release in the locus ceruleus of butorphanol- but not morphine-dependent rats. J.Pharmacol.Exp.Ther. 283 932.

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Keywords: Nor-Binaltorphimine Dihydrochloride, Opioid Receptors, Standard K Selective Antagonist, Nor-BNI, Norbinaltorphimine, NorBinaltorphimine Dihydrochloride, Tocris Bioscience

Literature in this Area

Scientific Reviews

Opioid Receptors
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