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Category: Ion ChannelsarrowLigand-gated Ion ChannelsarrowGABAA and GABAC ReceptorsarrowGABAA ReceptorsarrowAntagonists
Cat.No. Product Name
0131

(-)-Bicuculline methochloride  

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(-)-Bicuculline methochloride
Chemical Name: [R-(R*,S*)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodi oxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[ 4,5-g]isoquinolinium chloride

Biological Activity:

Methochloride salt of (+)-bicuculline. Water soluble and more stable than bicuculline. Non-GABA receptor-mediated actions reported.

Technical Data:

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M.Wt: 417.85
Formula: C21H20ClNO6
Storage: Store at RT
Solubility: Soluble to 100 mM in Water
Purity: >99%
CAS No: [53552-05-9]

Resources:

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    References:

    Kemp et al (1986) Quantitative evaluation of the potencies of GABA-receptor agonists and antagonists using the rat hippocampal slice preparation. Br.J.Pharmacol. 87 677. Seutin and Johnson (1999) Recent advances in the pharmacology of quaternary salts of bicuculline. TiPS 20 268.
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    Keywords: (-)-Bicuculline Methochloride, Ligand-gated Ion Channels, Water-soluble GABAA Antagonist, Bicuculline Methochloride, Tocris Bioscience

    Literature in this Area
    Scientific Reviews
    GABA Receptors
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    Signal Transduction Guide
    Signal Transduction Guide : An informative guide for all scientists working in: Cell cycle & apoptosis, Protein kinases & phosphatases, Ion channels, Calcium & lipid signaling, Cyclic nucleotides & G-proteins, Nitric oxide, & Signaling EnzymesA complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes.
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    Our laboratory loves dealing with Tocris and consider many of the compounds you sell to be far better quality than the compounds that we have received from other companies. Once again, thank you very much..”
    Researcher, Albany Medical College, USA
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