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Category: Ion ChannelsarrowLigand-gated Ion ChannelsarrowGABAA and GABAC ReceptorsarrowGABAA ReceptorsarrowAntagonists
Cat.No. Product Name
0109

(-)-Bicuculline methobromide  

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(-)-Bicuculline methobromide
Chemical Name: [R-(R*,S*)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodi oxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[ 4,5-g]isoquinolinium bromide

Biological Activity:

Methobromide salt of (+)-bicuculline. Water soluble and more stable than bicuculline. Non-GABA receptor-mediated actions reported.

Technical Data:

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M.Wt: 462.3
Formula: C21H20BrNO6
Storage: Store at RT
Solubility: Soluble to 50 mM in Water
Purity: >99%
CAS No: [73604-30-5]

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    References:

    Bowery et al (1983) Characteristics of GABAB receptor binding sites on rat whole brain synaptic membranes. Br.J.Pharmacol. 78 191. Sperber et al (1987) Nigral infusions of muscimol or bicuculline facilitate seizures in developing rats. Brain Res. 465 243. Seutin and Johnson (1999) Recent advances in the pharmacology of quaternary salts of bicuculline. TiPS 20 268.
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    Keywords: (-)-Bicuculline Methobromide, Ligand-gated Ion Channels, Water-soluble GABAA Antagonist, Bicuculline Methobromide, Tocris Bioscience
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    GABA Receptors
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