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Category: Ion ChannelsarrowLigand-gated Ion ChannelsarrowGABAA and GABAC ReceptorsarrowGABAA ReceptorsarrowAntagonists
Cat.No. Product Name
0130

(+)-Bicuculline  

Price and Availability

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(+)-Bicuculline
Chemical Name: [R-(R*,S*)]-6-(5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo[ 4,5-g]isoquinolin-5-yl)furo[3,4-e]-1,3-benzodioxol-8(6H )-one

Biological Activity:

Classical GABAA antagonist.

Technical Data:

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M.Wt: 367.36
Formula: C20H17NO6
Storage: Desiccate at +4°C
Solubility: Soluble to 5 mM in Ethanol and to 100 mM in DMSO
Purity: >99%
CAS No: [485-49-4]

Resources:

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    References:

    Merck Index 12 1250. Curtis et al (1970) GABA, bicuculline and central inhibition. Nature 226 1222. Olsen et al (1976) Studies on the neuropharmacological activity of bicuculline and related compounds. Brain Res. 102 283. Piredda et al (1985) Intracerebral site of convulsant action of bicuculline. Life Sci. 36 1295. Sieghart et al (1989) Multiplicity of GABAA-benzodiazepine receptors. TiPS 10 407.
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    Keywords: (+)-Bicuculline, Ligand-gated Ion Channels, Potent GABAA Antagonist, Bicuculline, Tocris Bioscience
    Literature in this Area
    Scientific Reviews
    GABA Receptors
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    Signal Transduction Guide
    Signal Transduction Guide : An informative guide for all scientists working in: Cell cycle & apoptosis, Protein kinases & phosphatases, Ion channels, Calcium & lipid signaling, Cyclic nucleotides & G-proteins, Nitric oxide, & Signaling EnzymesA complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes.
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