Click here for full price details of
Bafilomycin A1
Chemical Name:(3Z,5E,7R,8S,9S,11E,13E,15S,16R)-8-Hydroxy-16-[(1S,2R,3
S)-2-hydroxy-1-methyl-3-[(2R,4R,5S,6R)-tetrahydro-2,4-d
ihydroxy-5-methyl-6-(1-methylethyl)-2H-pyran-2-yl]butyl
]-3,15-dimethoxy-5,7,9,11-tetramethyloxacyclohexadeca-3
,5,11,13-tetraen-2-one
Biological Activity:
Highly potent, selective inhibitor of vacuolar H+-ATPases
(IC50 = 500 pM as measured in chromaffin granule membranes).
Selective over other ATP hydrolyzing enzymes such as F-ATPases, Ca2+-ATPases,
Na+/K+-ATPases and plasma membrane H+-ATPases.
Bowmanet al (1988) Bafilomycins: a class of inhibitors of
membrane ATPases from microorganisms, animal cells, and plant cells.
Proc.Natl.Acad.Sci.USA 85 7972.Palokangaset al (1998) Retrograde transport from the
pre-golgi complex is affected by the vacuolar H+-ATPase inhibitor
bafilomycin A1. Mol.Biol.Cell 8 3561. Gagliardiet al
(1999) Chemistry and stucture activity relationships of bafilomycin A1, a potent and selective
inhibitor of the vacuolar H+-ATPase. Curr.Med.Chem. 6 1197.
At Tocris we understand that planning an experiment is complicated and that it is important to be able to interact with knowledgeable people who care about helping you find the products and information you need.
Our specialist scientists provide the highest level of service for every enquiry, fully researching each one and supplying the most accurate response, quickly.
We encourage our customers to contact us; no question is too small or insignificant.
