BW-B 70C | Oxygenases / Oxidases | 5-Lipoxygenase Inhibitor | BWB 70C

Category:

Cat.No.	Product Name
1304	BW-B 70C

Price and Availability

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BW-B 70C

Chemical Name: N-[3-[3-(-Fluorophenoxy)phenyl]-1-methyl-2-propenyl]-N- hydroxyurea

Biological Activity:

A potent, selective inhibitor of 5-lipoxygenase. In vivo, has a long half-life and high oral bioavailability.

Technical Data:

M.Wt:	316.33
Formula:	C₁₇H₁₇FN₂O₃
Storage:	Desiccate at -20°C
Solubility:	Soluble to 3 mM in Ethanol and to 3 mM in DMSO
Purity:	>98%
CAS No:	[134470-38-5]

Resources:

Certificate of Analysis / MSDS:

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References:

Salmon et al (1990) Inhibition of 5-lipoxygenase: development of hydroxamic acids and hydroxyureas as potential therapeutic agents. Adv.Prost.Throm.Leuk.Res. 21 109. Payne et al (1991) Hydroxamic acids and hydroxyureas as novel, selective 5-lipoxygenase inhibitors for possible use in asthma. Agents Actions Suppl. 34 189. Yeadon et al (1993) Effect of BW B70C, a novel inhibitor of arachidonic acid 5-lipoxygenase, on allergen-induced bronchoconstriction and late-phase lung eosinophil accumulation in sensitised guinea-pigs. Agents Actions 38 8.

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Keywords: BW-B 70C, Oxygenases / Oxidases, 5-Lipoxygenase Inhibitor, BWB 70C, Tocris Bioscience

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