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Category:
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7TM Receptors 5-HT Receptors5-HT1 Receptors5-HT1D
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Cat.No.
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Product Name
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1207 |
BRL 15572 hydrochloride
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Price and Availability
Click here for full price details of
BRL 15572 hydrochloride
Other Information:
Sold with the permission of GlaxoSmithKline
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Chemical Name:
3-[4-(4-Chlorophenyl)piperazin-1-yl]-1,1-diphenyl-2-pro
panol hydrochloride |
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Biological Activity:
A selective h5-HT1D antagonist, displaying 60-fold
selectivity over h5-HT1B, and exhibiting little or no affinity for a
range of other receptor types.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Hagan et al (1997) Stimulation of 5-HT1B receptors
causes hypothermia in the rat. Eur.J.Pharmacol. 331 169. Price
et al (1997) SB-216641 and BRL-15572 - compounds to
pharmacologically discriminate h5-HT1B and h5-HT1D
receptors. Naunyn-Schmied.Arch.Pharmacol. 356 312. Schlicker
et al (1997) Effects of selective h5-HT1B (SB-216641) and
h5-HT1D (BRL-15572) receptor ligands on guinea-pig and human 5-HT
auto- and heteroreceptors. Naunyn-Schmied.Arch.Pharmacol. 356
321. Saxena et al (1998) 5-HT1-like receptors: a time
to bid goodbye. TiPS 19 311.
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Keywords: BRL 15572 Hydrochloride, 5-HT Receptors, Selective H5-HT1D Antagonist, BRL15572 Hydrochloride, Tocris Bioscience
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