BQ 788 | Peptides (Cardiovascular) | Selective ETB Antagonist | BQ788

Category:

Cat.No.	Product Name
1500	BQ 788 sodium salt

Price and Availability

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BQ 788

Chemical Name: N-[(cis-2,6-Dimethyl-1-piperidinyl)carbonyl]-4-methyl-L -leucyl-1-(methoxycarbonyl)-D-tryptophyl-D-norleucine sodium salt

Biological Activity:

Potent, selective ET_B receptor antagonist (IC₅₀ = 1.2 nM for inhibition of ET-1 binding to human Girardi heart cells).

Technical Data:

M.Wt:	663.79
Formula:	C₃₄H₅₀N₅NaO₇
Storage:	Desiccate at -20°C
Solubility:	Soluble in Ethanol and in DMSO
Purity:	>98%
CAS No:	[156161-89-6]

Resources:

Certificate of Analysis / MSDS:

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References:

Ishikawa et al (1994) Biochemical and pharmacological profile of a potent and selective endothelin B-receptor antagonist, BQ-788. Proc.Natl.Acad.Sci. 91 4892. Davenport (2002) International Union of Pharmacology. XXIX. Update on endothelin receptor nomenclature. Pharmacol.Rev. 54 219. Okada and Nishikibe (2002) BQ-788, a selective endothelin ET(B) receptor antagonist. Cardiovasc.Drug Rev. 20 53.

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Keywords: BQ 788, Peptides (Cardiovascular), Selective ETB Antagonist, BQ788, Tocris Bioscience

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