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Category:
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7TM Receptors Adrenergic ReceptorsAlpha-1 ReceptorsAntagonists
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Cat.No.
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Product Name
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1006 |
BMY 7378 dihydrochloride
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Price and Availability
Click here for full price details of
BMY 7378 dihydrochloride
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Chemical Name:
8-[2-[4-(methoxyphenyl)-1-piperazinyl]ethyl]-8-azaspir
o[4.5]decane-7,9-dione dihydrochloride |
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Biological Activity:
5-HT1A partial agonist and high affinity α1D adrenoceptor antagonist
(Ki values are 2, 800 and 600 nM at cloned rat α1D, rat α1A and hamster α1B receptors respectively).
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
Certificate of Analysis is currently unavailable on-line. Please contact Customer Service
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References:
Sharp et al (1990) Further investigation of the in vivo
pharmacological properties of the putative 5-HT1A antagonist, BMY
7378. Eur.J.Pharmacol. 176 331. Gruel and Glaser (1992)
The putative 5-HT1A receptor antagonists NAN-190 and BMY 7378 are
partial agonists in the rat dorsal raphe nucleus in vitro.
Eur.J.Pharmacol. 211 211. Piascik et al (1995) The
specific contribution of the novel alpha-1D adrenoceptor to the contraction of
vascular smooth muscle. J.Pharmacol.Exp.Ther. 275 1583. Yang
and Endoh (1997) Pharmacological evidence for α1D-adrenoceptors in the rabbit ventricular myocardium: analysis with
BMY 7378, Br.J.Pharmacol. 122 1541.
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Keywords: BMY 7378 Dihydrochloride, Adrenergic Receptors, Selective A1D Antagonist, 5-HT1A Partial Agonist, BMY7378 Dihydrochloride, Tocris Bioscience
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